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human soluble cd4 protein (scd4  (Progenics inc)

 
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    Progenics inc human soluble cd4 protein (scd4
    Increased plasma levels of <t>anti-CD4</t> IgG in HIV+ cocaine users and its effect on CD4+ T cell death through ADCC. This study included HIV-negative cocaine users (HIV–/D) and non-users (HIV–/ND), and aviremic ART-treated HIV+ cocaine users (HIV+/D) and non-users (HIV+/ND). The median plasma anti-CD4 IgG levels (A) and CD4+ T cell counts (B) and their correlations in HIV+ subjects (C) were evaluated. (D) The ADCC was performed in CD4+ T and NK cells in the presence of 5 µg/mL of purified anti-CD4 IgGs from ART-treated HIV+ cocaine users (HIV+/D), anti-CD4 IgGs from ART-naive HIV+ cocaine users (Neg1), total IgGs (Neg2) from ART-treated HIV+ cocaine users and an anti-CD4 mAb (Pos). The percent of CD4+ T cytolysis was assessed using flow cytometry. Non-parametric Mann–Whitney U and Spearman correlation tests. *p<0.05; **p<0.01.
    Human Soluble Cd4 Protein (Scd4, supplied by Progenics inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human soluble cd4 protein (scd4/product/Progenics inc
    Average 90 stars, based on 1 article reviews
    human soluble cd4 protein (scd4 - by Bioz Stars, 2026-06
    90/100 stars

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    1) Product Images from "The link between chronic cocaine use, B cell perturbations, and blunted immune recovery in HIV-infected individuals on suppressive ART"

    Article Title: The link between chronic cocaine use, B cell perturbations, and blunted immune recovery in HIV-infected individuals on suppressive ART

    Journal: Neuroimmune Pharmacology and Therapeutics

    doi: 10.1515/nipt-2022-0019

    Increased plasma levels of anti-CD4 IgG in HIV+ cocaine users and its effect on CD4+ T cell death through ADCC. This study included HIV-negative cocaine users (HIV–/D) and non-users (HIV–/ND), and aviremic ART-treated HIV+ cocaine users (HIV+/D) and non-users (HIV+/ND). The median plasma anti-CD4 IgG levels (A) and CD4+ T cell counts (B) and their correlations in HIV+ subjects (C) were evaluated. (D) The ADCC was performed in CD4+ T and NK cells in the presence of 5 µg/mL of purified anti-CD4 IgGs from ART-treated HIV+ cocaine users (HIV+/D), anti-CD4 IgGs from ART-naive HIV+ cocaine users (Neg1), total IgGs (Neg2) from ART-treated HIV+ cocaine users and an anti-CD4 mAb (Pos). The percent of CD4+ T cytolysis was assessed using flow cytometry. Non-parametric Mann–Whitney U and Spearman correlation tests. *p<0.05; **p<0.01.
    Figure Legend Snippet: Increased plasma levels of anti-CD4 IgG in HIV+ cocaine users and its effect on CD4+ T cell death through ADCC. This study included HIV-negative cocaine users (HIV–/D) and non-users (HIV–/ND), and aviremic ART-treated HIV+ cocaine users (HIV+/D) and non-users (HIV+/ND). The median plasma anti-CD4 IgG levels (A) and CD4+ T cell counts (B) and their correlations in HIV+ subjects (C) were evaluated. (D) The ADCC was performed in CD4+ T and NK cells in the presence of 5 µg/mL of purified anti-CD4 IgGs from ART-treated HIV+ cocaine users (HIV+/D), anti-CD4 IgGs from ART-naive HIV+ cocaine users (Neg1), total IgGs (Neg2) from ART-treated HIV+ cocaine users and an anti-CD4 mAb (Pos). The percent of CD4+ T cytolysis was assessed using flow cytometry. Non-parametric Mann–Whitney U and Spearman correlation tests. *p<0.05; **p<0.01.

    Techniques Used: Purification, Flow Cytometry, MANN-WHITNEY



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    Fig. 4 Binding enhancement of mAbs and their fragments to Env in the presence of <t>sCD4.</t> Binding activity to 293T cells expressing Env of JR-FL was examined using flow cytometry. Histogram of fluorescence intensity shows the binding of negative control (gray), mAb alone (blue) and in the presence of sCD4 (red). Enhancement of binding by <t>CD4</t> engagement against trimeric Env expressed on the cellular surface was observed for anti- CD4i IgG as well as their fragments
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    Increased plasma levels of anti-CD4 IgG in HIV+ cocaine users and its effect on CD4+ T cell death through ADCC. This study included HIV-negative cocaine users (HIV–/D) and non-users (HIV–/ND), and aviremic ART-treated HIV+ cocaine users (HIV+/D) and non-users (HIV+/ND). The median plasma anti-CD4 IgG levels (A) and CD4+ T cell counts (B) and their correlations in HIV+ subjects (C) were evaluated. (D) The ADCC was performed in CD4+ T and NK cells in the presence of 5 µg/mL of purified anti-CD4 IgGs from ART-treated HIV+ cocaine users (HIV+/D), anti-CD4 IgGs from ART-naive HIV+ cocaine users (Neg1), total IgGs (Neg2) from ART-treated HIV+ cocaine users and an anti-CD4 mAb (Pos). The percent of CD4+ T cytolysis was assessed using flow cytometry. Non-parametric Mann–Whitney U and Spearman correlation tests. *p<0.05; **p<0.01.

    Journal: Neuroimmune Pharmacology and Therapeutics

    Article Title: The link between chronic cocaine use, B cell perturbations, and blunted immune recovery in HIV-infected individuals on suppressive ART

    doi: 10.1515/nipt-2022-0019

    Figure Lengend Snippet: Increased plasma levels of anti-CD4 IgG in HIV+ cocaine users and its effect on CD4+ T cell death through ADCC. This study included HIV-negative cocaine users (HIV–/D) and non-users (HIV–/ND), and aviremic ART-treated HIV+ cocaine users (HIV+/D) and non-users (HIV+/ND). The median plasma anti-CD4 IgG levels (A) and CD4+ T cell counts (B) and their correlations in HIV+ subjects (C) were evaluated. (D) The ADCC was performed in CD4+ T and NK cells in the presence of 5 µg/mL of purified anti-CD4 IgGs from ART-treated HIV+ cocaine users (HIV+/D), anti-CD4 IgGs from ART-naive HIV+ cocaine users (Neg1), total IgGs (Neg2) from ART-treated HIV+ cocaine users and an anti-CD4 mAb (Pos). The percent of CD4+ T cytolysis was assessed using flow cytometry. Non-parametric Mann–Whitney U and Spearman correlation tests. *p<0.05; **p<0.01.

    Article Snippet: Briefly, we coated the ELISA plate with human soluble CD4 protein (sCD4, Progenics, Tarrytown, NY).

    Techniques: Purification, Flow Cytometry, MANN-WHITNEY

    Fig. 4 Binding enhancement of mAbs and their fragments to Env in the presence of sCD4. Binding activity to 293T cells expressing Env of JR-FL was examined using flow cytometry. Histogram of fluorescence intensity shows the binding of negative control (gray), mAb alone (blue) and in the presence of sCD4 (red). Enhancement of binding by CD4 engagement against trimeric Env expressed on the cellular surface was observed for anti- CD4i IgG as well as their fragments

    Journal: Retrovirology

    Article Title: Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes.

    doi: 10.1186/s12977-017-0369-y

    Figure Lengend Snippet: Fig. 4 Binding enhancement of mAbs and their fragments to Env in the presence of sCD4. Binding activity to 293T cells expressing Env of JR-FL was examined using flow cytometry. Histogram of fluorescence intensity shows the binding of negative control (gray), mAb alone (blue) and in the presence of sCD4 (red). Enhancement of binding by CD4 engagement against trimeric Env expressed on the cellular surface was observed for anti- CD4i IgG as well as their fragments

    Article Snippet: Recombinant human soluble CD4 (sCD4) was purchased commercially (R&D Systems Inc., Minneapolis, MN, USA).

    Techniques: Binding Assay, Activity Assay, Expressing, Flow Cytometry, Fluorescence, Negative Control